"Differential Effects of Unsaturated Fatty Acids and Saturated Fatty Acids on Lipotoxicity and Neutral Lipid Accumulation in Neuro-2a Cells"

نویسندگان

چکیده

CJ Urso and Heping Zhou* Author Affiliations Department of Biological Sciences, Seton Hall University, South Orange, NJ 07079, USA Received: July 14, 2021 | Published: 27, Corresponding author: Zhou, DOI: 10.26717/BJSTR.2021.37.006017

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Antagonism Between Saturated and Unsaturated Fatty Acids in ROS Mediated Lipotoxicity in Rat Insulin-Producing Cells.

BACKGROUND/AIMS Elevated levels of non-esterified fatty acids (NEFAs) are under suspicion to mediate β-cell dysfunction and β-cell loss in type 2 diabetes, a phenomenon known as lipotoxicity. Whereas saturated fatty acids show a strong cytotoxic effect upon insulin-producing cells, unsaturated fatty acids are not toxic and can even prevent toxicity. Experimental evidence suggests that oxidative...

متن کامل

Combined effect of unsaturated fatty acids and saturated fatty acids on the metabolic syndrome: tehran lipid and glucose study

AIMS The aim of this study was to investigate whether the background intakes of total dietary fat, monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) modulate the effects of dietary saturated fatty acids (SFA) on metabolic syndrome (MetS). MATERIAL AND METHODS This population-based cross-sectional study was conducted on a representative sample of 4,677 adults, aged 19 t...

متن کامل

Isolation and determination methods for brain cerebrosides, hydroxy fatty acids, and unsaturated and saturated fatty acids *

A new method is described for the isolation of nearly pure total cerebrosides from fresh brain. Florisil columns are used to separate the cerebroside hydroxy and normal acids, in the form of their esters, and to separate the saturated and unsaturated esters of each group. The esters within each class are determined by gas chromatography, the hydroxy esters being run as the methyl ethers. Yields...

متن کامل

Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes.

Fatty acid-induced lipotoxicity plays a critical role in the pathogenesis of nonalcoholic liver disease. Saturated fatty acids and unsaturated fatty acids have differential effects on cell death and steatosis, but the mechanisms responsible for these differences are not known. Using cultured HepG2 cells and primary mouse hepatocytes, we found that unsaturated and saturated fatty acids different...

متن کامل

Unsaturated fatty acids and pain.

Fatty acids, which are the essential nutrients for humans, are an important source of energy and an essential component of cell membranes. They also function as signal transduction molecules in a range of biological phenomena. Recently, an increasing number of physiologic and pharmacologic reports on fatty acids have improved our understanding of the association of fatty acids with certain dise...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Biomedical Journal of Scientific and Technical Research

سال: 2021

ISSN: ['2574-1241']

DOI: https://doi.org/10.26717/bjstr.2021.37.006017